Neutering prevents reproduction and is usually a permanent surgical procedure. Castration removes the testes; spaying removes the ovaries, with or without the uterus. Surgery may also be needed to treat reproductive disease. Its benefits and risks should be discussed with a veterinarian experienced in degu medicine.
Potentially distressing surgical photographs are hidden behind labelled spoiler panels. You can read the article without opening them.
Benefits and risks

Potential benefits
- Preventing reproduction: avoiding unwanted litters, pregnancy and the difficulty of finding suitable homes for pups.
- Behaviour: castration may reduce hormonally influenced aggression in some males. It does not guarantee compatibility or resolve every territorial conflict.
- Social management: a neutered male may be able to live with females once the postoperative fertility risk has passed and introductions have been managed safely.
- Avoiding pregnancy-related risks: spaying prevents pregnancy. Females can become fertile again soon after giving birth, so prevention of repeated pregnancies matters.
- Treating or preventing selected diseases: removal of affected reproductive organs may be indicated for uterine infection, tumours or other conditions. The benefit depends on which organs are removed and the individual diagnosis.
Potential disadvantages
- Anaesthesia and surgical complications: risks include anaesthetic problems, bleeding, infection and impaired recovery.
- Behavioural and hormonal changes: responses vary and improvement cannot be promised.
- Age and development: timing requires an individual assessment of health, size, reproductive risk and the reason for surgery. Circadian development studies do not establish that neutering before one year halts brain development.
- Weight management: monitor food intake, activity, weight and body condition after surgery. A fixed 300 g ceiling is not appropriate for every degu.
- Irreversibility: removal of the gonads permanently removes fertility.
- Recovery and stress: surgery requires monitoring, pain relief and appropriate postoperative care.
- Specialist experience: a veterinarian familiar with degu anatomy and anaesthesia is important.
Puberty, skeletal growth and maturation of circadian rhythms are different processes. A study of circadian development cannot be used to declare a universal adult age of 53–55 weeks or a universal minimum surgical age. Published degu surgical research includes animals older than six months, but this is not itself a recommendation to operate on every animal at that age.
Spaying females
Female surgery can be more involved than male castration and may be undertaken for a medical indication, including reproductive tumours or pregnancy complications. The choice between ovariectomy and ovariohysterectomy depends on the clinical situation.
Published approaches include a ventral midline approach and bilateral flank ovariectomy. The large intestinal tract requires careful handling to expose the reproductive organs. The surgeon controls the ovarian blood supply and, when the uterus is removed, secures the uterine vessels and cervix, checks for bleeding and closes the tissues appropriately. These are specialist procedures, not techniques to attempt outside veterinary practice.

Castrating males
Published techniques include prescrotal and scrotal open approaches. A study comparing them found the prescrotal procedure faster; an anaesthesia-related death occurred in the scrotal group. This illustrates that even routine population-control surgery carries risk.
The surgeon exposes the testes, carefully dissects surrounding fatty tissue and secures the spermatic cords. An abdominal approach is another option in selected circumstances. The approach and closure are chosen by the operating veterinarian.

Postoperative care
Follow the discharge instructions closely, including prescribed pain relief, wound checks and monitoring of eating, droppings and activity. Keep the enclosure clean and temporarily remove the sand bath until your veterinarian considers the wound sufficiently healed. Contact the clinic promptly for reduced appetite, lethargy, swelling, bleeding or damage to the wound.
A recently castrated male may retain viable sperm. Do not regard 10–15 days as a proven safe interval for degus. Keep him apart from fertile females for the period specified by the operating veterinarian, and make a careful reintroduction only after medical clearance.

Making the decision
Neutering may be appropriate to prevent breeding or treat disease, but it is never risk-free. Discuss the individual animal and the intended social group with an experienced veterinarian. Group stability depends on compatibility, introductions and housing as well as reproductive status.
Sources
Palacios, A. G. & Lee, T. M. (2013). Husbandry and Breeding in the
Octodon degu
(Molina 1782). Cold Spring Harbor Protocols, 2013(4), pdb.prot 073577. https://doi.org/10.1101/pdb.prot073577
Lee, T. M., et al. (2004). Pubertal development of sex differences in circadian function: an animal model. Ann N Y Acad Sci, 1021, 262-275. https://doi.org/10.1196/annals.1308.031
Mancinelli, E., Eatwell, K. & Meredith, A. (2013). Successful Management of a Case of Pregnancy Failure in a Degu (Octodon degus). Journal of Exotic Pet Medicine, 22(3), 293-300. https://doi.org/10.1053/j.jepm.2013.08.012
Quesenberry, K. E., et al. (Eds.) (2021). Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery (4th ed.). Elsevier/Saunders. https://evolve.elsevier.com/cs/product/9780323484350?role=faculty
Malbrue, R. A., et al. (2019). EVALUATION OF ORCHIECTOMY AND OVARIECTOMY SURGICAL TECHNIQUES IN DEGUS (OCTODON DEGUS). Journal of Exotic Pet Medicine, 30, 22-28. https://doi.org/10.1053/j.jepm.2018.08.003
